Researchers find genetic variants that increase Alzheimer’s risk

Researchers at Boston University announced Thursday a groundbreaking discovery about a gene associated with the risk of Alzheimer’s disease. This risk is linked to the APOE4 gene, which destroys brain cells if a person carries the gene. This puts them at a higher risk of developing the disease, although inheriting the gene does not necessarily mean one will develop the disease, according to the NIH. The APOE3 gene is the most common and is not known to affect Alzheimer’s risk. Although the link between the gene and the disease is well established, the mechanism responsible for the underlying risk in brain cells was not not clear in research until recently discovered, according to researchers from the BU School of Medicine. Alzheimer’s is a progressive neurodegenerative disease and is the most common cause of dementia. It affects more than 5.8 million individuals in the United States. In the recent discovery, two important aspects of the gene have been discovered – the human genetic background associated with the gene is unique to APOE 4 patients and the genetic defects are unique to human cells. “Our study demonstrated what the APOE4 gene does and which brain cells are most affected in humans by comparing human and mouse models. These are important findings because we can find therapies if we understand how and where this risky gene is destroying our brains,” said Julia TCW, assistant professor at BU School of Medicine. The researchers used three models to study the gene’s effects on brain cells. , human induced pluripotent stem cells, post-mortem human brains and experimental models. The gene is also known to carry a risk of Parkinson’s disease and rare genetic diseases.

Researchers at Boston University announced Thursday a groundbreaking discovery about a gene associated with the risk of Alzheimer’s disease.

This risk is linked to the APOE4 gene, which destroys brain cells if a person carries the gene. This puts them at a higher risk of developing the disease, although inheriting the gene does not necessarily mean that one will develop the disease, according to the NIH. The APOE3 gene is the most common and is not known to affect Alzheimer’s risk.

Although the link between the gene and the disease is well established, the mechanism responsible for the underlying risk in brain cells was unclear in research until the recent discovery, according to researchers from the BU School of Medicine. .

Alzheimer’s disease is a progressive neurodegenerative disease and is the most common cause of dementia. It affects more than 5.8 million people in the United States.

In the recent discovery, two important aspects of the gene have been discovered – the human genetic background associated with the gene is unique to APOE 4 patients and the genetic defects are unique to human cells.

“Our study demonstrated that APOE4 which gene does and which brain cells are most affected in humans by comparing human and mouse models. These are important findings because we can find treatments if we understand how and where this risky gene is destroying our brains,” said Julia TCW, assistant professor at BU Medical School.

The researchers used three models to study the gene’s effects on brain cells, human induced pluripotent stem cells, post-mortem human brains, and experimental models.

The gene is also known to carry a risk of Parkinson’s disease and rare genetic diseases.

>

Leave a Comment